Information research is an iterative process, meaning a cycle rather than a straight line.
(Please note: the following refers to literature searching; in chemistry, you might also do substance or reaction searching.)
Confession: I often start a research quest with a simple Google search. Keeping in mind that not all the information I find on the web is going to be reliable, Google is still a good way to get my feet wet with a topic and gather the relevant vocabulary I need. Then I can move on to a more targeted database search.
Example
What is the chemistry behind how melanin protects our skin from the sun?
Step 1: Break up this research question into two or three main concepts. Ignore extraneous words.
Step 2: Conduct an initial search with these words, and quickly scan the results.
Step 3: Using information from your initial search, add synonyms, acronyms, and variant spellings.
(melanin OR melanogenesis OR melanocyte OR pigmentation) AND (sun OR ultraviolet OR uv) AND (protection OR shield)